Natural Therapeutics
Detoxification
Detoxification Nutraceuticals: Activated charcoal, C60, liposomal glutathione, sulforaphane, zeolites, chlorella, spirulina, methylation nutrients (B6, B9, B12, SAM-e, MSM), magnesium, selenium, iodine, digestive/systemic enzymes, schizandra, milk thistle, modified citrus pectin, N-acetylcysteine (NAC), shilajit, Tauroursodeoxycholic acid (TUDCA)
Recommended Products:
David Wolfe Kohlbitr Activated Charcoal
Dietary Detoxification (organic): Whole-foods plant-rich diet with emphasis on cruciferous vegetables (sulforaphane, DIM, Indole-3-Carbinol), allium vegetables, turmeric, citrus fruits, berries, beets (betaine), apples, avocado (glutathione), black radish
Lifestyle Detoxification: Colon hydrotherapy, coffee enemas, rebounding, dry skin brushing, saunas, exercise, juice/water fasting, removing mercury amalgams and root canals, proper oral hygiene, eliminating toxic chemical-based body and cleaning products
Parasite Detoxification: Cloves, black walnut, wormwood, enzymes, mimosa pudica, coated silver, diatomaceous earth (food-grade), raw garlic, pumpkin seeds, papaya seeds, turpentine oil, neem, copper, oregano oil
Recommended Anti-Parasitics:
Why is detoxification so important?
Advances in Understanding How Heavy Metal Pollution Triggers Gastric Cancer (BioMed Research International, 2016)
“There are four potential mechanisms by which heavy metals induce gastric cancer. Heavy metals disrupt the gastric mucosal barrier and lead to inflammation, tissue damage, and dysplastic lesions in the stomach glandular epithelium. Almost all heavy metals cause DNA lesions and enhance invasion and metastasis by cancer cells by generating ROS. Heavy metals also inhibit DNA damage repair or result in inefficient lesion repair and induce other gene abnormalities. In addition, heavy metals induce the expression of proinflammatory chemokine interleukin-8 (IL-8) and microRNAs in gastric cancer development.”
The Lancet Commission on Pollution and Health reported that diseases caused by pollution were responsible for an estimated 9 million premature deaths in 2015—16% of all deaths worldwide. Pollution accounts for more deaths than AIDS, tuberculosis, and malaria combined, fifteen times more than all wars and other forms of violence. Pollution takes more lives than smoking, hunger, and natural disasters.
A recent study published in The Journal of the American Medical Association titled “Excretion of the Herbicide Glyphosate in Older Adults Between 1993 and 2016” revealed findings that can no longer be ignored. The study found that exposure to glyphosate among the participants had increased by 500% in the past two decades. Glyphosate is banned in fourteen countries and on the list of chemicals that can cause cancer under California's Proposition 65.
Improving Gut Microbiome
High-quality, multi-strain probiotics w/ prebiotics... In general, taking supplements that contain both probiotics and prebiotics increases the amount of probiotics that survive in the intestinal tract, creating a synbiotic effect which has greater effects than either alone
Full-spectrum digestive enzymes
L-glutamine
Green kiwifruit; Contains the naturally occurring proteolytic enzyme (unique to kiwifruit) actinidin, which aids protein digestion both in the stomach and small intestine, and the peptide Kissper, which has been shown to exhibit strong anti-inflammatory effects within the gastrointestinal tract, significantly reducing bloating and gastric discomfort. The daily consumption of two kiwifruit has been found to increase stool frequency, including the number of complete spontaneous bowel motions per week, reduce gastrointestinal transit time and improve measures of intestinal comfort (European Journal of Nutrition). Adding to the gastrointestinal benefits, kiwi is a prebiotic fruit that selectively enhances the growth of beneficial microorganisms in the gut, specifically Bifidobacterium, Lactobacillus, and F. prausnitzii.
The effect of 'Zesy002' kiwifruit (Actinidia chinensisvar. chinensis) on gut health function: a randomised cross-over clinical trial
“A total of thirty-two participants were enrolled in a 16-week randomised, single-blind, crossover study. Participants received either three 'Zesy002' kiwifruit or 14·75 g Metamucil® (5 g dietary fibre/d (a positive control)) for 4 weeks each with a 4-week washout between treatments. A 2-week washout period was included at the beginning and end of the study. Daily bowel habit diaries were kept throughout the study. The primary outcome measure was differences in the number of complete spontaneous bowel movements (CSBM). Secondary outcome measures were bowel movement frequency and stool form as well as digestive symptoms and comfort. The number of CSBM per week was significantly greater during daily consumption of three kiwifruit compared with the baseline and the Metamucil® treatment. Stool consistency was also improved, with kiwifruit producing softer stools and less straining. Gastrointestinal discomfort was also improved compared with baseline for abdominal pain, constipation and indigestion during the kiwifruit intervention and constipation during the Metamucil® intervention. This randomised controlled trial demonstrates that daily consumption of three gold-fleshed kiwifruit is associated with a significant increase of two CSBM per week and reduction in gastrointestinal discomfort in mildly constipated adults.” (Journal of Nutritional Science, 2019)
Raw apple cider vinegar; Rich in enzymes, probiotics, and acids (acetic acid, malic acid) which stabilize stomach acid, promote healthy pH of the stomach, and aid digestion
Diet rich in prebiotics: Aloe vera (fructans, acemannan), resistant starch (buckwheat groats, green bananas, cooked and cooled rice/potatoes, beans, lentils, plantains, yucca/cassava root), raw honey, microalgae (especially spirulina), beta-glucans (medicinal mushrooms, seaweed, oats), fructans which consist of inulin and fructo-oligosaccharides (jicama, yacon, artichokes, asparagus, onions, garlic, leeks, agave, chicory, bananas), pectins (apples, citrus), arabinoxylans (cereal grains), phytonutrients (polyphenols such as those found in pomegranates, walnuts, cacao, and grapes, and anthocyanins such as those found in blueberries and purple sweet potatoes)
Diet rich in fermented foods: Kimchi, sauerkraut, tempeh, kombucha, coconut yogurt, water kefir
Natural Laxatives: Triphala, senna, castor oil, aloe vera, flaxseeds, magnesium oxide (Oxy-Powder), sea salt flush,
Ginger; Reduces gas, indigestion and bloating, and improves overall digestive function
Activated charcoal… Binds to unhealthy bacteria, endotoxins, and poisons within the gastrointestinal tract and removes them from the body, protects the gut microbiome from antibiotics, reduces gas and bloating
Natural Antibiotics: Coated silver, iodine, medicinal mushrooms, raw manuka honey (high UMF), multi-strain probiotics, full spectrum hemp extract, royal jelly, high-dose vitamin C, ozone (can be applied topically or via ozone inhalation therapy or blood ozonation), berberine
Demulcents: Irish Sea moss, chia, honey, berries, marshmallow, slippery elm
Improving Microbiome Diversity: Gardening (soil microbes also have anti-depressant effects; 1 teaspoon of soil contains between 100 million to 1 billion microbes), shin-rin yoku (forest bathing), sunlight (skin-gut-axis)/vitamin D, exercise (increases F. prausnitzii, A. muciniphila, butyrate-producing bacteria, decreases C. difficile), diet rich in prebiotic fibers, phytonutrients and fermented foods, multi-strain probiotics, living with pets, avoiding factors that damage the gut microbiome
What damages the gut microbiome? Antibiotics/antibacterials, pesticides, tap water, poor diet, artificial sweeteners, processed foods, diet rich in animal fat/protein, diet low in prebiotic fibers, phytonutrients, & fermented foods, nutritional deficiencies, pharmaceutical and recreational drugs, chronic stress, sleep deprivation, exposure to toxicity (air pollution, toxic household/hygiene products, poor diet, heavy metals, etc.), excess alcohol, caesarean section birth, poor oral health…
More than 25% of non-antibiotic drugs induce dysbiosis of the microbiome: “We found that PPIs, metformin, NSAIDs, opioids, statins and antipsychotics have an impact on the overall architecture of the gut microbiome. PPI, metformin, NSAIDs, opioids and antipsychotics were associated with increases in members of Gammaproteobacteria. Specific taxonomic profiles associated with PPI use may potentiate colonisation by pathogenic bacteria, especially C. difficile” (Alimentary Pharmacology and Therapeutics, 2018). Dysbiosis is a microbial ecosystem in which bacteria no longer live in a mutualistic association and lose overall diversity.
Cancer
Curcuminoids & turmerones
Clinical effects of curcumin in enhancing cancer therapy: A systematic review (BMC Cancer, 2020)
“Overall, the results suggest that curcumin can be used as an effective combination in inhibiting and controlling cancers, improving clinical symptoms and preventing tumor spread and metastasis. This compound would affect various molecular pathways and inhibits vasodilation, cell proliferation, and metastasis… Curcumin is a natural product found in turmeric that has a unique chemical structure, with particular biological and medicinal properties. Through various cellular and molecular mechanisms, curcumin inhibits the carcinogenesis and their growth. Due to the fact that no specific toxic effects of this natural product have been reported, its use has been considered as a drug supplement in therapeutic diets of cancer patients. In a number of studies considered in this systematic review have shown that taking curcumin would increase the expression of anti-metastatic proteins. In several other studies, it was reported that curcumin has also increased patient survival and decreased tumor marker concentration.”
Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways (Frontiers in Oncology, 2021)
“Natural compounds have been well known for their potential effect on preventing cancer progression and as complementary or stand-alone therapies for cancer treatment. As a natural phenolic compound, curcumin is extracted from the dietary spice turmeric, showing an important significance in the adjuvant treatment of tumors with non-toxicity and tolerability. Curcumin participates in tumor control through multiple signaling pathways, including PI3K/Akt, JAK/STAT, MAPK, Wnt/β-catenin, p53, NF-ĸB and apoptosis related signaling pathways. In addition, it is well known that ncRNA (including miRNA and lncRNA) plays an important role in the development of tumors. Curcumin regulates the expression of ncRNAs, which in turn affects the expression of related signaling pathway genes/proteins, and ultimately inhibits tumor cell proliferation, promotes cell apoptosis, and enhances sensitivity to chemotherapy drugs. These findings will help us better understand the molecular mechanism between curcumin and ncRNAs in anti-tumor, and the potentiality of clinical adjuvant treatment. Collectively, curcumin is a natural compound with potential drug value in adjuvant treatment of tumors.”
Phase IIA Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia (Cancer Prev Res, 2011)
“In conclusion, we have demonstrated that a short duration of curcumin treatment reduces ACF number. Our finding that oral, 98%-pure curcumin significantly reduced ACF number in humans confirms preclinical observations regarding changes in ACF in response to curcuminoid mixtures (consisting of curcumin, bisdemethoxy, and demethoxycurcumin) but leaves the mechanism(s) by which this occurs unanswered. The treatment-related increase in conjugate concentrations in plasma suggests that the ACF reduction resulted from systemic rather than local delivery of conjugates. These data verify the data of others that despite lack of systemically bioavailable concentrations of curcumin, anticarcinogenesis activity occurs at tissue targets. If these results can be confirmed in further trials in high-risk adenoma populations and if the mechanisms by which ACF reduction occurs after the administration of curcumin can be identified, they would further support the use of curcumin as a cancer prevention agent while strengthening the utility of ACF as a biomarker for clinical colon-cancer studies.”
Sulforaphane
Chemopreventive activity of sulforaphane (Drug Design, Development and Therapy, 2018)
“Human clinical studies have supported the chemopreventive effects of SFN on carcinogenesis. The clinical Phase I and Phase II studies showed that broccoli sprout extracts containing SFN were well tolerated and caused no significant adverse effects in healthy volunteers, women with breast cancer, and men with recurrent prostate cancer. In addition, a recent study reported that SFN effectively inhibited tumor growth and increased the sensitivity of cancer cells to chemotherapeutics in patients with advanced pancreatic ductal adenocarcinoma… Based on the above-mentioned studies, it is clear that the SFN is a safe and relatively nontoxic chemopreventive agent, and exerts anticancer activities through multiple mechanisms, including regulation of Phase I and Phase II DMEs, anti-inflammatory activity, cell cycle arrest, induction of apoptosis, and the epigenetic regulation on Nrf2-Keap1, cyclins, and CDKs. Further understanding of the cancer chemopreventive activities of SFN will allow us to assess its efficacy in human cancers as a single agent or as part of combination strategies in various types of human cancers.”
Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts (Future Oncology, 2013)
“Many studies have supported the protective effects of broccoli and broccoli sprouts against cancer. The chemopreventive properties of sulforaphane, which is derived from the principal glucosinolate of broccoli and broccoli sprouts, have been extensively studied. Recent research into the effects of sulforaphane on cancer stem cells (CSCs) has drawn lots of interest. CSCs are suggested to be responsible for initiating and maintaining cancer, and to contribute to recurrence and drug resistance. A number of studies have indicated that sulforaphane may target CSCs in different types of cancer through modulation of NF-κB, SHH, epithelial-mesenchymal transition and Wnt/β-catenin pathways. Combination therapy with sulforaphane and chemotherapy in preclinical settings has shown promising results.”
Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway (Oxidative Medicine and Cellular Longevity, 2018)
“Based on the above-mentioned studies, it is clear that the dietary compound SFN, which has little or no adverse side effects, exerts anticancer activities through multiple mechanisms, including epigenetic regulation. Thus, daily consumption of cruciferous vegetables rich in SFN is not only a healthy diet choice but also an effective chemopreventive strategy. SFN, as an inducer of Nrf2, shows the capacity to reactivate Nrf2 expression and its target cytoprotective genes to prevent carcinogenesis through epigenetic mechanisms, namely, CPG demethylation and histone acetylation of the Nrf2 promoter, via inhibition of DNMTs and HDACs. These studies have prompted us to propose epigenetic restoration of Nrf2 by SFN as an important strategy against oxidative damage-related diseases, including cancer, which may provide new research directions and preventive approaches for oxidative damage-related diseases.”
Medicinal mushrooms (chaga, reishi, turkey tail, shiitake, maitake, antrodia etc.)
Potential of Mushroom Compounds as Immunomodulators in Cancer Immunotherapy: A Review (Evidence-Based Complementary and Alternative Medicine, 2018)
“Bioactive compounds from mushrooms have been shown to activate or modulate the immune system, thereby inhibiting cancer cell metastasis and growth. These compounds work by affecting the maturation, differentiation, and proliferation of immune cells. The major compounds of immune and cancer importance target the gut system, especially intestines as their site of contact and primary action, thereby affecting intestinal immunity and ultimately systemic immunity. These compounds are PAMP (pathogen associated molecular patterns) and act by interacting with receptors on leucocytes, upregulate genes associated with immunity, increase production of T lymphocytes and cytokines, activate activity of macrophages and cytokines, induce apoptosis, affect cell cycle, and increase infiltration of cytotoxic T cells in tumors. Critical studies on the mechanism of action and development of anticancer agents from mushrooms are very important so as to reduce the burden of cancer and improve quality of life of cancer patients. More than 50 mushroom species have yielded potential immunoceuticals with immunomodulatory and antitumor effects in vitro and in vivo and also in human cancers. They include lectins, polysaccharides, polysaccharides-peptides, polysaccharide-protein complexes like lentinan, schizophyllan, polysaccharide-K, polysaccharide P, active hexose correlated compounds (AHCC), and Maitake D fraction.”
Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (Frontiers in Pharmacology, 2019)
“Twenty-three trials involving 4,246 cancer patients were included in this work. C. versicolor and G. lucidum related natural products were significantly associated with lower risks of mortality and higher total efficacy… In this meta-analysis, we found that C. versicolor and G. lucidum related natural products could increase the OS (Overall Survival) in cancer patients. Besides, it seems likely that the products provide clinical and life quality benefits for cancer patients with low side effects. Large sample size and high-quality randomized controlled trial (RCT) in different continents with various types and stages of cancer are needed to further evaluate the effect of the products on patients in the future.”
Antrodia Cinnamomea Prolongs Survival in a Patient with Small Cell Lung Cancer (Medicina, 2019)
“Outcomes: DAC caused the tumor to shrink substantially. Surprisingly, the patient survived for 32 months without relapse after six months of DAC treatment. Laboratory examinations indicated that the patient’s health had improved significantly, reverting to near normal levels. Notably, he had a good quality of life with a high Barthel index score. Unfortunately, this patient died of septic shock caused by acute cholangitis. Conclusion: DAC may exert an anti-cancer effect, which can lead to tumor regression. This is supposed to be achieved by the combined DAC’s immunomodulatory, anti-angiogenic, anti-metastatic, anti-proliferative, and pro-apoptotic effects mediated through multiple signaling pathways. We propose that DAC can be used as a complementary medicine to prolong the life expectancy and improve the life quality of SCLC patients.”
Lentinan as an immunotherapeutic for treating lung cancer: a review of 12 years clinical studies in China (Journal of Cancer Research and Clinical Oncology, 2018)
“The structure and function relationship and underlying molecular mechanism of lentinan as an immunostimulant has been summarized. The mean value of overall response rate in treating lung cancer was increased from 43.3% of chemotherapy alone to 56.9% of lentinan plus chemotherapy. Compared with chemotherapy alone, lentinan plus chemotherapy showed more efficacy in treating lung cancer and no statistical heterogeneity was found among studies… Conclusion: Clinical data presented in the past 12 years shows that lentinan is effective not only in improving quality of life, but also in promoting the efficacy of chemotherapy during lung cancer treatment.”
Full-spectrum cannabinoids
Cannabidiol (CBD) as a Promising Anti-Cancer Drug (Cancers, 2020)
“As evidenced by the large volume of literature reviewed above, CBD has demonstrated robust anti-proliferative and pro-apoptotic effects on a wide variety of cancer types both in cultured cancer cell lines and in mouse tumor models. In comparison, CBD generally has milder effects on normal cells from the same tissue/organ. The anti-tumor mechanisms vary based on tumor types, ranging from cell cycle arrest to autophagy, to cell death, or in combination. In addition, CBD can also inhibit tumor migration, invasion, and neo-vascularization, suggesting that CBD not only acts on tumor cells but can also affect the tumor microenvironment, for example by modulating infiltrating mesenchymal cells and immune cells. The dependency of CBD on the endocannabinoid receptors, CB1 and CB2, or the TRPV family of calcium channels, also varies, suggesting that CBD may have multiple cellular targets and/or different cellular targets in different tumors. Mechanistically, CBD seems to disrupt the cellular redox homeostasis and induce a drastic increase of ROS and ER stress, which could then exert the cell cycle arrest, autophagy, and cell death effects. For future studies, it is crucial to elucidate the interplays among different signaling transduction pathways, such as ROS, ER stress, and inflammation, in order to better understand how CBD treatment disrupts cellular homeostasis in both tumor cells as well as infiltrating cells, leading to cancer cell death and inhibition of tumor migration, invasion, metastasis, and angiogenesis. The final step of developing CBD as an oncology drug is through extensive and well-designed clinical trials, which are urgently needed.”
Cannabinoids in Glioblastoma Therapy: New Applications for Old Drugs (Frontiers in Molecular Neuroscience, 2018)
“Glioblastoma (GBM) is the most malignant brain tumor and one of the deadliest types of solid cancer overall. Despite aggressive therapeutic approaches consisting of maximum safe surgical resection and radio-chemotherapy, more than 95% of GBM patients die within 5 years after diagnosis. Thus, there is still an urgent need to develop novel therapeutic strategies against this disease. Accumulating evidence indicates that cannabinoids have potent anti-tumor functions and might be used successfully in the treatment of GBM... The therapeutic effect of cannabinoids is based on reduction of tumor growth via inhibition of tumor proliferation and angiogenesis but also via induction of tumor cell death. Additionally, cannabinoids were shown to inhibit the invasiveness and the stem cell-like properties of GBM tumors. Recent phase II clinical trials indicated positive results regarding the survival of GBM patients upon cannabinoid treatment. Taken together these findings underline the importance of elucidating the full pharmacological effectiveness and the molecular mechanisms of the cannabinoid system in GBM pathophysiology... In conclusion, cannabinoids show promising anti-neoplastic functions in GBM by targeting multiple cancer hallmarks such as resistance to programmed cell death, neoangiogenesis, tissue invasion or stem cell-induced replicative immortality. The effects of cannabinoids can be potentially enhanced by combination of different cannabinoids with each other or with chemotherapeutic agents. This requires, however, a detailed understanding of cannabinoid-induced molecular mechanisms and pharmacological effects. Ultimately, these findings might foster the development of improved therapeutic strategies against GBM and, perhaps, other diseases of the nervous system as well.”
Anticancer mechanisms of cannabinoids (Current Oncology, 2016)
In addition to the well-known palliative effects of cannabinoids on some cancer-associated symptoms, a large body of evidence shows that these molecules can decrease tumour growth in animal models of cancer. They do so by modulating key cell signalling pathways involved in the control of cancer cell proliferation and survival. In addition, cannabinoids inhibit angiogenesis and decrease metastasis in various tumour types in laboratory animals… To summarize, cannabinoids induce tumour cell death and inhibit tumour angiogenesis and invasion in animal models of cancer, and there are indications that they act similarly in patients with glioblastoma. Given that cannabinoids show an acceptable safety profile, clinical trials testing them as single drugs or, ideally, in combination therapies in glioblastoma and other types of cancer are both warranted and urgently needed.”
Vitamin D
Effects of Long-Term Vitamin D Supplementation on Regression and Metabolic Status of Cervical Intraepithelial Neoplasia: a Randomized, Double-Blind, Placebo-Controlled Trial (Hormones & Cancer, 2017)
“This study was performed to evaluate the effects of long-term vitamin D administration on regression and metabolic status of patients with CIN1. This randomized, double-blind, placebo-controlled trial was performed among 58 women diagnosed with CIN1… In conclusion, vitamin D3 administration for 6 months among women with CIN1 resulted in its regression and had beneficial effects on markers of insulin metabolism, plasma NO, TAC, GSH and MDA levels.”
Effect of Vitamin D3 Supplements on Development of Advanced Cancer: A Secondary Analysis of the VITAL Randomized Clinical Trial (JAMA Network Open, 2020)
“In summary, this randomized clinical trial of daily high-dose vitamin D supplementation for 5 years reduced the incidence of advanced (metastatic or fatal) cancer in the overall cohort of adults without a diagnosis of cancer at baseline, with strongest risk reduction in individuals with normal weight. Additional randomized trials focusing on cancer patients should be considered, as well as investigations of differential benefit by BMI. Even if vitamin D effects were modest, vitamin D supplementation at the studied levels are much less toxic and lower cost than many current cancer therapies.”
The effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials (British Journal of Cancer, 2020)
“This is the first systematic review with meta-analysis of randomised controlled trials to examine the effect of vitamin D supplementation on survival outcomes in patients with CRC. We found that supplementation imparts a 30% reduction in adverse survival outcomes overall, with a 24% reduction in CRC-specific death and a 33% in disease progression or death. The effect on survival was consistently observed in sub-group analyses both in trials specifically including CRC patients and in population trials reporting outcomes in incident CRC cases… In conclusion, this meta-analysis demonstrates a clinically meaningful beneficial effect from vitamin D supplementation on survival outcomes in patients with CRC. Further well-designed, adequately powered RCTs are needed to fully evaluate the benefit of supplementation in augmenting ‘real-world’ follow-up and adjuvant chemotherapy regimens, as well as determining optimal dosing.”
Circulating vitamin D level and mortality in prostate cancer patients: a dose–response meta-analysis (Endocrine Connections, 2020)
“The results calculated from seven eligible studies indicated higher vitamin D level was significantly associated with decreased all-cause mortality and prostate cancer-specific mortality. Further dose–response analysis showed that every 20 nmol/L increment in 25-hydroxyvitamin D level was associated with a 9% lower risk of all-cause mortality and prostate cancer-specific mortality… Based on the results mentioned earlier, we can draw the conclusion that higher vitamin D level is significantly associated with a risk reduction of all-cause mortality and prostate cancer-specific mortality, indicating vitamin D may exert a protective effect in the progression and prognosis of prostate cancer. More cohort studies and randomized clinical trial are needed to further illustrate the role of vitamin D in the pathogenesis and prognosis of prostate cancer.”
Skin Cancer: BEC5 (Eggplant), Nicotinamide
Solasodine glycoalkaloids: a novel topical therapy for basal cell carcinoma. A double‐blind, randomized, placebo‐controlled, parallel group, multicenter study (International Journal of Dermatology, 2007)
“A cream containing solasodine glycosides has been formulated and tested in Australia (licensed in 1991 and marketed as “Curaderm”) for solar keratosis. In an open controlled clinical trial of 28 patients with 62 lesions, complete regression was observed in 20 of 24 BCCs, 5 of 6 squamous cell carcinomas (SCC), and all 23 cases of solar keratoses. There were no systemic adverse effects and no recurrence in patients followed for 5 years… We investigated the efficacy and safety of Zycure cream, containing 0.005% of solasodine glycosides (mainly solasonine and solamargine) in the treatment of BCCs… Ninety‐four patients were randomized on a 2 : 1 ratio. Histologically confirmed lesions were treated double blinded, twice daily under occlusion with Zycure or vehicle for 8 weeks. Patients were reviewed fortnightly for adverse effects and overall response. Successfully treated patients were followed up at six‐month intervals for a year. Conclusion: We conclude that the solasodine glycoside cream Zycure is a safe therapy for basal cell carcinoma, with a cure rate of 66% at 8 weeks and 78% at 1 year follow‐up.”
Treatment of Skin Cancer with a Selective Apoptotic-Inducing CuradermBEC5 Topical Cream Containing Solasodine Rhamnosides (International Journal of Clinical Medicine, 2015)
“Solasodine rhamnosides produced in plants as secondary metabolites, are safe and effective when treating a variety of cancers, including non-melanoma skin cancers. They are cytotoxic against multi-drug resistant tumor cells, stimulate lasting immunity against cancer, are not mutagenic and display anti-mutagenic properties. These antineoplastics, through cellular specific receptor-mediated actions, directly induce apoptosis by triggering extrinsic and intrinsic apoptotic pathways in cancer cells but not normal cells. CuradermBEC5 contains solasodine rhamnosides and is a topical formulation for the treatment of keratoses and non-melanoma skin cancers. The mode of action, together with the selectivity towards cancer cells, with CuradermBEC5 therapy, results in outstanding beneficial outcomes. This study shows graphically and pictorially that CuradermBEC5 seeks and destroys basal cell carcinoma whilst normal skin cells replace the dead cancer cells during therapy, emanating into impressive cosmetic end results. The clinical observations with CuradermBEC5 therapy reveal that initially the lesion size increases over four-fold due to the interaction of CuradermBEC5 with deeper and more lateral tumor cells, followed by a decrease in size, ultimately, resulting in complete elimination of the basal cell carcinoma.”
A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention (The New England Journal of Medicine, 2015)
“In this phase 3, double-blind, randomized, controlled trial, we randomly assigned, in a 1:1 ratio, 386 participants who had had at least two nonmelanoma skin cancers in the previous 5 years to receive 500 mg of nicotinamide twice daily or placebo for 12 months. Participants were evaluated by dermatologists at 3-month intervals for 18 months. The primary end point was the number of new nonmelanoma skin cancers (i.e., basal-cell carcinomas plus squamous-cell carcinomas) during the 12-month intervention period. Secondary end points included the number of new squamous-cell carcinomas and basal-cell carcinomas and the number of actinic keratoses during the 12-month intervention period, the number of nonmelanoma skin cancers in the 6-month postintervention period, and the safety of nicotinamide… At 12 months, the rate of new nonmelanoma skin cancers was lower by 23% in the nicotinamide group than in the placebo group… Conclusions: Oral nicotinamide was safe and effective in reducing the rates of new nonmelanoma skin cancers and actinic keratoses in high-risk patients.”
Cruciferous Vegetables
The Epigenetic Impact of Cruciferous Vegetables on Cancer Prevention (Current Pharmacology Reports, 2015)
“Many studies have contributed to the incorporation of dietary agents as forms of cancer remediation. Cruciferous vegetables are enriched with several chemical components that have tremendous negative effects on multiple pathways of cancer cells due to their anti-proliferative and anti-tumorigenic properties. The consumption of these vegetables is beneficial in the sense that they are precursors to glucosinolates which give rise to isothiocyanates such as sulforaphane and indoles such as indole-3-carbinol. Most cancers are characterized by the overexpression of HDAC and DNMT and the mis-expression of miRNAs. Both I3C and SFN are inhibitors and regulators of these processes and the incorporation of these compounds causes cancerous cell lines to take on a healthier, and more normalized appearance. In addition, significant decreases in uncontrolled cell growth as well as increases in programed cell death are noticed with the incorporation of SFN and I3C. Many studies reveal that cruciferous vegetables are key instruments in advancing progress toward the prevention of cancer. Future studies will undoubtedly be directed toward further deciding the epigenetic events impacted by the bioactive components of cruciferous vegetables and their significance with respect to not only cancer prevention, but also many other biological processes.”
Cruciferous vegetables intake is inversely associated with risk of breast cancer: a meta-analysis (Breast, 2013)
“Results: Thirteen epidemiologic studies (11 case-control and 2 cohort studies) were included in the meta-analysis. The combined results from all studies indicated that high cruciferous vegetables intake was significantly associated with reduced breast cancer risk.”
Intake of cruciferous vegetables is associated with reduced risk of ovarian cancer: a meta-analysis (Asia Pacific Journal of Clinical Nutrition, 2015)
“Eight studies (4 case-control studies and 4 cohort studies) were identified and included in this meta-analysis. When all studies were pooled together, there was a significantly inverse association between CV consumption and the risk of ovarian cancer. No significant heterogeneity or publication bias was found… The findings from this study suggest that the consumption of CVs may reduce the risk of ovarian cancer.”
Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis (World Journal of Surgical Oncology, 2015)
“Four cohort and five case-control studies were eligible for inclusion. We found a significantly decreased risk of pancreatic cancer associated with the high intake of cruciferous vegetables… Cruciferous vegetable intake might be inversely associated with pancreatic cancer risk. Because of the limited number of studies included in this meta-analysis, further well-designed prospective studies are warranted to confirm the inverse association between cruciferous vegetable intake and risk of pancreatic cancer.”
Phycocyanin
Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies (Life, 2021)
“Dried biomass products of Arthrospira and Chlorella have been categorized as “generally recognized as safe” (GRAS) by the US Food and Drug Administration (FDA). Of particular importance is an ingredient of Arthrospira: phycocyanin, a blue-red fluorescent, water-soluble and non-toxic biliprotein pigment. It is reported to be the main active ingredient of Arthrospira and was shown to have therapeutic properties, including anti-oxidant, anti-inflammatory, immune-modulatory and anti-cancer activities… The data indicate that PC (phycocyanin) may be considered a safe drug to reduce or inhibit tumor cell growth. The combination with other anti-cancer drugs and/or radiation therapy might allow the reduction of the effective dose of established anti-cancer drugs, which would minimize dose-related side effects and improve the therapeutic outcome. Also, encapsulation of PC might prolong the half-lifetime, and could thus improve the effectiveness.”
Bioactive Compounds of Arthrospira spp. (Spirulina) with Potential Anticancer Activities: A Systematic Review (ACS Chem Biology, 2021)
“A total of 1306 articles were independently assessed according to the eligibility criteria, of which 20 articles were selected and assessed for the risk of bias using seven criteria developed by the authors. Arthrospira spp. of cyanobacteria have been evaluated against eight different types of cancer, mainly colon cancer. Among all the compounds, phycocyanin was the most used, followed by peptides and photosensitizers. In general, compounds from Arthrospira spp. act as anticancer agents by inhibiting the proliferation of tumor cells, triggering cell cycle arrest, and inducing apoptosis via different signaling pathways. In addition, these compounds also exhibited antioxidant, antiangiogenic, and antimetastatic activities. Phycocyanin demonstrated better efficacy against several types of cancer via different activities and therapeutic targets. Furthermore, it was the only molecule that functioned in synergy with other drugs that are already well established for the treatment of cancer.”
Cardiovascular Disease
Nutrients: Vitamin K2, omega-3's (EPA/DHA), CoQ10 (Ubiquinol), vitamin C, Niacin (b3)
The Inhibitory Roles of Vitamin K in Progression of Vascular Calcification (Nutrients, 2020)
“Vascular calcification is an inflammation-mediated process in which activated transdifferentiation of VSMCs into osteoblastic cells was induced by the action of cytokines such as TNF-α and OSM secreted from macrophages infiltrated in intimal and medial tissues of arterial wall. Vitamin K may prevent vascular calcification through an anti-inflammatory mechanism as well as promotion of γ-carboxylation of MGP. The preventive role of active MGP in vascular calcification has been proven by several clinical studies demonstrating the procalcific effect of warfarin, a vitamin K antagonist in arteries. Various clinical studies have revealed that higher vitamin K intake may reduce the risk of vascular calcification and CVD and higher plasma concentrations of dp-ucMGP may predict future risk of death or CV events. High-quality prospective cohort studies and RCTs are still required to establish the role of vitamin K in CV health.”
Association of dietary vitamin K and risk of coronary heart disease in middle-age adults: the Hordaland Health Study Cohort (BMJ Open, 2020)
“Conclusion: In this Norwegian community-based study population, we observed that intake of K2 was associated with lower risk of CHD, while there was no association between intake of K1 and CHD. These results are considered generalisable to other middle-aged Western populations in which dairy products are the primary source of K2.”
Coenzyme Q10: Clinical Applications in Cardiovascular Diseases (Antioxidants, 2020)
“Conclusion: Clinical evidence supports supplementation with high doses of bioavailable-CoQ10 (≥200 mg/day) to support heart health in patients affected by coronary heart disease and heart failure, partly modulating a number of risk factors for these conditions, and partly directly acting on myocardial cell metabolism. Long-term RCTs are still needed to confirm and better understand the efficacy and safety profile of this molecule in a large number of patients and CV diseases.”
Effect of Omega-3 Dosage on Cardiovascular Outcomes: An Updated Meta-Analysis and Meta-Regression of Interventional Trials (Mayo Clinic Proceedings, 2021)
“The current study presents strong evidence that EPA+DHA supplementation is an effective strategy for the prevention of certain CVD outcomes, and that for CVD events and MI the protective effect appears to increase with dosage. Authoritative bodies issuing intake recommendations and health care providers need to consider taking these results into account. Considering the relatively low costs and side effect profiles of omega-3 supplementation and the low drug-drug interactions with other standard therapies used in primary and secondary CVD prevention, clinicians and patients should consider the potential benefits of omega-3 (EPA/DHA) supplementation, especially using 1000 to 2000 mg/day dosages, which are rarely obtained in most Westernized diets, even those including some routine fish consumption.”
Nattokinase
A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia (Zhonghua Yi Xue Za Zhi, 2017)
“Results: A total of 82 patients were enrolled in the study and 76 patients (NK 39, ST 37) completed the study. Following the treatments for 26 weeks, there was a significant reduction in CCA-IMT and carotid plaque size in both groups compared with the baseline before treatment… The reduction in the NK group was significantly profound (36.6% reduction in plaque size in NK group versus 11.5% change in ST group). Both treatments reduced total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG)… In addition, NK significantly increased the level of high-density lipoprotein cholesterol (HDL-C)… Conclusions: Our findings from this pioneer clinical study suggests that daily NK supplementation is an effective way to manage the progression of atherosclerosis and potentially may be a better alternative to statins which are commonly used to reduce atherosclerosis and further to prevent cardiovascular attack and stroke in patients. The mechanism underlying the reduction of carotid atherosclerosis by NK may be independent from its lipid-lowering effect, which is different from that of statins.”
Nattospes as Effective and Safe Functional Supplements in Management of Stroke (Journal of Medicinal Food, 2020)
“Stroke remains a major cause of human disability worldwide. Interventions and rehabilitation at the poststroke stage are critical for recovery. A single-blinded randomized controlled trial was conducted on 61 patients diagnosed with subacute stage of ischemic stroke. Ingestion of Nattospecs was tested as an adjuvant to support rehabilitation when combined with standard of care (SOC) treatment (electroacupuncture and Naatrapyl) (Trial group) and compared to SOC treatment alone (Control group). After 60 days, results showed that both Trial and Control groups achieved significant improvements in physical activities, blood pressure control, serum lipid panels, and quality of life. Nattospes as a food supplement has good supportive effects on treatment and rehabilitation after ischemic stroke by showing statistically significant improvement of stroke-related symptom in scores from modified Rankin, Orgogozo, and Barthel scales. In addition, Nattospes showed a good safety profile, with no adverse effects reported in both clinical and paraclinical parameters. This study indicated that Nattospes as nutraceutical supplement can be applied safely and effectively in the management of subacute stage ischemic stroke.”
Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases (Biomarker Insights, 2018)
“The most unique feature of NK is that, as a single compound, it possesses multiple CVD preventative and alleviating pharmacologic effects (namely, antithrombotic, antihypertensive, anticoagulant, anti-atherosclerotic, and neuroprotective effects). There are no other drugs or drug candidates with multiple pharmacologic properties similar to NK. In addition, NK is a natural product that can be administered orally, has a proven safety profile, is economical to use, and provides distinct advantages over other pharmaceutical products. It therefore has the potential to be developed as a new-generation drug for the prevention, treatment, and long-term care of CVD… The emerging picture of NK is one of the unique natural compounds with many favourable health effects, especially for patients with CVD. Importantly, NK simultaneously effects several key favourable benefits for thrombosis, hypertension, atherosclerosis, hyperlipidaemia, platelet aggregation, and neuroprotection in patients with CVD. These multiple benefits to patients make the role of NK very unique in the prevention and treatment of CVD with reduced side effects commonly associated with conventional CVD drugs. In addition to the unique multiple functions of NK, other advantages to the patient include ease of oral administration, a robust safety profile and a long in vivo half-life.”
Data Recorded in Real Life Support the Safety of Nattokinase in Patients with Vascular Diseases (Nutrients, 2021)
“Nattokinase (NK) is a serine protease enzyme with fibrinolytic activity. Even if it could be used for the treatment of several diseases, no data have been published supporting its use patients who underwent vascular surgery. In this study, we evaluated both the efficacy and the safety of nattokinase (100 mg/day per os) in patients admitted to vascular surgery. Patients were of both sexes, >18 years of age, with vascular diseases (i.e., deep vein thrombosis, superficial vein thrombosis, venous insufficiency), and naïve to specific pharmacological treatments (anticoagulants or anti-platelets). Patients were divided into three groups. Group 1: patients with deep vein thrombosis, treated with fondaparinux plus nattokinase. Group 2: patients with phlebitis, treated with enoxaparin plus nattokinase. Group 3: patients with venous insufficiency after classical surgery, treated with nattokinase one day later. During the study, we enrolled 153 patients (age 22–92 years), 92 females (60.1%) and 61 males (39.9%;), and documented that nattokinase was able to improve the clinical symptoms without the development of adverse drug reactions or drug interactions. Among the enrolled patients, during follow-up, we did not record new cases of vascular diseases. Attention to patients’ clinical evolution, monitoring of the INR, and timely and frequent adjustment of dosages represent the cornerstones of the safety of care for patients administered fibrinolytic drugs as a single treatment or in pharmacological combination. Therefore, we can conclude that the use of nattokinase represents an efficient and safe treatment able to both prevent and treat patients with vascular diseases.”
Plant-Based Diet
Plant-Based Diet: A Potential Intervention for Heart Failure (Cureus, 2020)
“Heart failure is a disease that increases the likelihood of morbidity and mortality with an increased direct and indirect cost to the healthcare system. The role of diet in the development, progression and treatment of heart failure is being studied with growing interest. The objective of this study is to assess the relationship between heart failure and selected heart failure risk factors: hyperlipidemia, hypertension, diabetes mellitus and plant-based diets as a clinical intervention. The search yielded 416 published articles, among them are three studies that used a plant-based diet as an intervention for heart failure. All interventional studies showed that plant-based diets have a positive impact on heart failure in terms of improved ejection fraction and positive cardiac muscle remodeling… Pischke et al. in 2007 conducted an analysis on the effects of plant-based diets on ejection fraction in patients with heart disease. In 46 patients with left ventricular ejection fraction impairment, all patients were put on a plant-based diet for three months and were followed throughout. They found that all heart failure risk factors have improved during that period along with exercise tolerance. This finding shows that plant-based diets have a direct positive impact on clinical outcomes of heart failure in this sample group… In 2017, Choi et al. reported one heart failure case with ejection fraction of 35% and left ventricular systolic dysfunction. This patient was on plant-based diet for two months. The outcome of the intervention showed major changes in ejection fraction as it normalized to 50% and other heart failure risk factors improved significantly over that period… In 2019, Najjar and Montgomery reported three cases of heart failure patients who were put on plant-based diets for an average of 79 days. All patients showed a major improvement in heart failure risk factors and blood markers, and substantial changes in heart structure and function where ejection fraction improved by 92%, LV mass reduced by 21%, stroke-volume increased by 62% and overall, cardiac output increased by 17% in the patient group.”
Consumption of a defined, plant-based diet reduces lipoprotein(a), inflammation, and other atherogenic lipoproteins and particles within 4 weeks. (Clinical Cardiology, 2018)
“A defined, plant-based diet has a favorable impact on Lp(a), inflammatory indicators, and other atherogenic lipoproteins and particles. Lp(a) concentration was previously thought to be only minimally altered by dietary interventions. In this protocol however, a defined plant-based diet was shown to substantially reduce this biomarker. Further investigation is required to elucidate the specific mechanisms that contribute to the reductions in Lp(a) concentrations, which may include alterations in gene expression.”
Lifestyle: Sauna
Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study (BMC Medicine, 2018)
“Conclusions: Higher frequency and duration of sauna bathing are each strongly, inversely, and independently associated with fatal CVD events in middle-aged to elderly males and females. The frequency of sauna bathing improves the prediction of the long-term risk for CVD mortality.”
Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence (Mayo Clinic Proceedings, 2018)
“Sauna bathing, an activity that has been a tradition in Finland for thousands of years and mainly used for the purposes of pleasure and relaxation, is becoming increasingly popular in many other populations. Emerging evidence suggests that beyond its use for pleasure, sauna bathing may be linked to several health benefits, which include reduction in the risk of vascular diseases such as high blood pressure, cardiovascular disease, and neurocognitive diseases; nonvascular conditions such as pulmonary diseases; mortality; as well as amelioration of conditions such as arthritis, headache, and flu. The beneficial effects of sauna bathing on these outcomes have been linked to its effect on circulatory, cardiovascular, and immune functions. It has been postulated that regular sauna bathing may improve cardiovascular function via improved endothelium-dependent dilatation, reduced arterial stiffness, modulation of the autonomic nervous system, beneficial changes in circulating lipid profiles, and lowering of systemic blood pressure.”
Depression & Anxiety
Nutrients: Omega-3's (EPA/DHA), B6/B9/B12, vitamin D, magnesium, iodine, amino acids
Establishing a healthy gut microbiome
Detoxification
Cannabidiol (CBD)
CBD inhibits FAAH, which is an enzyme in the body that breaks down anandamide. Anandamide is known as the “bliss” molecule as it uplifts mood and well-being, calms the nerves, enhances sensory pleasure and reduces pain. Furthermore, CBD induces neurogenesis (the growth of new brain cells), synaptogenesis (the growth of synapses between neurons in the nervous system), and increases Brain Derived Neurotrophic Factor (BDNF).
Lions mane (Hericium erinaceus)
This mushroom's exceptional brain-boosting powers lie in its ability to stimulate synthesis of Nerve Growth Factor (NGF), a protein that plays a major role in the maintenance and regeneration of neurons in both your central and peripheral nervous systems. Lion's mane contains two unique types of NGF-inducing compounds: hericenones and erinacines. The erinacines found in lion's mane mycelium are among the most powerful NGF inducers in the natural world, able to cross the blood-brain barrier and stimulate the production of new neurons within the brain itself. Lion's mane is said to bestow the "nerves of steel and the memory of a lion" upon those who consume it. Overall, lions mane is a nootropic (substance used to enhance cognitive functions).
E3 Live BrainON
Aphanizomenon flos-aquae (AFA) contains phenylethylamine (PEA), commonly referred to as the "love molecule" as high levels of this chemical is released in the brain when one has feelings of falling in love. Phenylethylamine is a neuromodulator with powerful anti-depressant effects and increases the ability to concentrate. When the brain is flooded with PEA the neurotransmitter dopamine is then hindered from being broken down and dopamine levels rise. In addition, PEA increases the release of serotonin and norepinephrine, and research has shown that patients with clinical depression have lower levels of PEA.
L-Theanine
N-Acetylcysteine (NAC)
Adaptogens: Schizandra, panax ginseng, ashwagandha, holy basil (tulsi)
Magnesium-L-Threonate
Lifestyle: Forest bathing (shinrin-yoku), exercise, deep breathing, meditation
Immune System
Nutrients: Vitamin D, iodine (nascent iodine such as Detoxadine), zinc (w/ quercetin enhances effects), vitamin C, vitamin A, selenium
Medicinal mushrooms (chaga, reishi, turkey tail, shiitake, maitake, antrodia, etc.)
Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China (Discovery Medicine, 2017)
“Conventional cancer treatments include surgery, chemotherapy, and radiation therapy. In recent years, immunotherapy in cancer care has been gaining momentum. Interestingly, an immunotherapeutic regime that employs polysaccharopeptide (PSP), a unique peptide-containing polysaccharide isolated from Coriolus versicolor, has already become a routine clinical practice in Japan since 1977 and in China since 1987. Coriolus versicolor is one of the most well-known traditional food and medicinal mushrooms in China for thousands of years. Medically used PSP is mostly obtained from the extraction of cultured Coriolus versicolor mycelia where β-glucan is the major component. PSP has proven beneficial to survival and quality of life not only for cancer patients but also for patients with hepatitis, hyperlipidemia, and other chronic diseases. In this article, the results of PSP-related preclinical and clinical studies conducted in China from over 40 independent studies during the past 40 years based on searching the Chinese VIP, CNKI, and Wanfang databases are presented. Its immunomodulatory and anti-tumor molecular mechanisms are also summarized. PSP activates immune cells, increases the expressions of cytokines and chemokines such as tumor necrosis factor-α (TNF-α), interleukins (IL-1β and IL-6), histamine, and prostaglandin E, enhances dendritic and T-cell infiltration into tumors, and ameliorates the adverse events associated with chemotherapy. The clinical studies support PSP being a potential immunotherapeutic. However, the complicated chemical and multiple pharmacological properties of PSP need to be investigated further.”
Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia (International Journal of Medicinal Mushrooms, 2018)
“This study demonstrates that β-glucans from G. lucidum increase the frequency of immune system cells in the peripheral blood; these cells are critical in the defense against infectious threats in asymptomatic children 3 to 5 years old. These findings warrant longer controlled clinical trials that aim to evaluate the efficacy of β-glucans in preventing infections in healthy children and to define their potential to enhance lymphoid cell number and functions in various lymphoid immune deficiencies.”
High-quality, multi-strain probiotics w/ prebiotics
Coated silver
Elderberry extract
Andrographis
Panax ginseng
Liposomal glutathione
Establishing a healthy gut microbiome
Aged garlic extract and fresh raw garlic (crushed)
Lifestyle: Water fasting, sauna
Women's Health
Healthy phytoestrogens: Soy isoflavones (fermented organic soy products such as tempeh, miso, and natto), schizandra, hops extract (8-Prenylnaringenin), pomegranate, flax, red clover, black cohosh, chickpeas
Detoxifying xenoestrogens: Raw cruciferous vegetables (DIM and I3C), methylation nutrients (B6, B9, B12, SAM-e, MSM), calcium D-glucarate (apples, oranges, grapefruit, cruciferous vegetables), eliminating exposure to xenoestrogens (plastics, phthalates, PCB’s, parabens, etc.)
Increasing progesterone: Chasteberry, maca, vitamin C, detoxifying xenoestrogens
Enhancing sexual function: Panax ginseng, maca, fenugreek, royal jelly, ginkgo biloba
Menopause support: Healthy phytoestrogens, detoxifying xenoestrogens, royal jelly, black cohosh, Siberian rhubarb extract, schizandra
Polycystic Ovarian Syndrome: Healthy phytoestrogens, licorice, D-Chiro-Inositol & Myo-Inositol, black cohosh, liver detoxification (to eliminate excess androgens), vitamin D
Endometriosis: DIM (Diindolylmethane), iodine, vitamin D, alpha lipoic acid, N-acetylcysteine (NAC)
Improving fertility: Chasteberry/maca/methylfolate combo, N-acetylcysteine (NAC)
A Patented Blend Consisting of a Combination of Vitex agnus-castus Extract, Lepidium meyenii (Maca) Extract and Active Folate, a Nutritional Supplement for Improving Fertility in Women (Maedica, 2019)
“Average age of the women was 31.18 years (SD 5.18 years). There was a successful pregnancy rate of 37%, with no difference between the two arms of the study. The number of new pregnancies was relatively constant through the study duration. The number of women with ovulation increased from 10% to 42.9% by the end of the study. During the six-month-period of the study, there were no side effects reported between patients of the two groups… Conclusions: The supplement may be used by women trying to conceive. The patented blend consisting of a combination of Vitex, Maca and active folate regulates the menstrual cycle, stimulates ovulation and increases the likelihood of getting pregnant”
Men's Health
Increasing testosterone: Shilajit, ashwagandha, pine pollen, panax ginseng, fenugreek extract, tongkat ali, aromatase inhibitors, sufficient sleep, detoxifying xenoestrogens
Aromatase inhibitors: Nettle root, passionflower
Enhancing sexual function: Panax ginseng, maca, cistanche, mucuna, black ginger extract, horny goat weed, muira puama, fenugreek, vitamin D (necessary for adequate erectile function)
Improving fertility: Maca, mucuna, ashwagandha, panax ginseng, walnuts, N-acetylcysteine (NAC)
Kidney Health
Activated charcoal
Rehmannia
Cordyceps militaris (highest cordycepin content)
Reishi
Nutrients: Omega-3's
Kidney stones: Fresh lemon/lime juice (citric acid), chanca piedra “stone breaker”, raw apple cider vinegar
Eliminate animal protein, stay hydrated, lower blood pressure
Cucumber juice (contains erepsin, an enzyme that breaks down excessive protein in kidneys)
Black foods: According to Traditional Chinese Medicine, black foods/herbs increase kidney jing. Examples include black “forbidden” rice, black beans, black sesame seeds/tahini, shilajit, he shou wu
Sleep/Insomnia
Full-spectrum CBD
Ashwagandha
Ziziphus (Chinese jujube seed)
Magnesium-L-Threonate
Glycine
L-Theanine
Raw honey
Lifestyle: Exercise,
Nutraceuticals: Cymbiotika Rumi, Global Healing Hemp Extract
Attention Deficit Hyperactivity Disorder (ADHD)
Nutrients: B6/B9/B12, Omega-3's (EPA/DHA), Vitamin D
E3 Live BrainON
Panax ginseng
Full-spectrum CBD
Bacopa
Magnesium-L-Threonate
L-Theanine
Alzheimer's Disease
Nattokinase
Curcumin
Ashwagandha
Magnesium-L-Threonate
Full-spectrum CBD
Lions mane
Bacopa
Healthy oral hygiene; The main pathogen of chronic periodontitis, Porphyromonas gingivalis, is a serious risk factor for developing Alzheimer’s disease
Lifestyle: Hyperbaric oxygen therapy
Hypothyroidism
Nutrients: Nascent iodine (except in Hashimoto's, only food-based iodine), selenium, zinc, iron, vitamin A, vitamin D
Ashwagandha
Hashimoto's: Selenium, myo-inositol
Reducing rT3: Panax ginseng
Causes of high rT3: High cortisol (excess or prolonged stress), toxicity, liver dysfunction
What to avoid: Alcohol, gluten, goitrogens, soy, chlorine, bromine, fluoride, pesticides, plastics
Establishing a healthy gut microbiome
Consequences: Hypochlorhydria (low stomach acid), liver disease, insulin resistance, hair loss/thinning
High Cholesterol
Nutrients: Niacin, vitamin D
Curcumin
Berberine
Alpha lipoic acid
Red yeast rice
Chlorella & Spirulina
Amla extract
Foods rich in phytosterols such as avocados, amaranth, pistachios, oats, saw palmetto, maca, chaga, seeds and nuts, extra-virgin olive oil
Liver Health
Nutrients: Lecithin, choline
Liposomal glutathione
N-acetylcysteine (NAC)
Coffee enemas
Organic coffee (drinking)
Curcuminoids & turmerones
See Detoxification Nutraceuticals
What to avoid: Alcohol, dietary cholesterol, red meat (production of TMAO)
Hair Loss
Nutrients: Iodine, biotin (vitamin B7), zinc, L-cysteine, silica
Inhibiting Dihydrotestosterone (DHT): Saw palmetto, reishi, pumpkin seed oil, sulforaphane, rosemary oil